This is one of those narratives that can be manipulated by how one defines the 'founder'. Quite a few companies were started by one person, but did not become successful until someone else with a strong business acumen (and usually higher education) took over. An axiom of invention is that the invention is not truly successful until a great number of people use it and benefit from it.
Especially true in the late 19th and early 20th century, where tradesmen came up with an interesting invention, but lacked the business or financial acumen to make it truly successful.
Let's look at a few...
IBM was a combination of several related companies. Herman Hollerith invented an electric tabulating machine that used punch cards to record information, and the machine summed up the data. Hollerith was college educated. William Bundy invented a time punch machine for workers to record time in and time out. Charles Flint put the companies together, not because he was a brilliant inventor, but because he had the financial backing and the business acumen to see that the related inventions would work well together. He was also college educated.
To complicate the picture further, IBM did not really rise to prominence until Thomas Watson became the president. He oversaw their entrance into, and dominance of, the new electronic computers in the 1950's, culminating in the first scalable computer line with common programming languages, the 360. It was the concept of 'write program once, run on many types of computers' that made IBM's computers so successful, they were the first to do this. Previously, coding was done in machine language, specific to the machine.
The IBM of today is more Thomas Watson's creation than anyone.
General Electric. It began as Edison Electric, founded by Thomas Edison, to promote his DC power, aided by his patron, John Pierpoint Morgan. However, when Edison's DC power was found to be inferior to Tesla's AC power for sending the power over great distances, Morgan took control of the company (he had bought controlling interest when Edison kept asking for more investment), merged it with Thomas-Houston Electric who built early AC generators, and renamed it General Electric. Edison wasn't really the founder of GE, as his idea failed. Morgan built GE into a giant, by virtue of his financial resources and business expertise. Edison was not college educated, Morgan was.
Boeing was begun by William Boeing, who attended Yale but did not graduate. He had purchased an early Curtiss airplane, was taught to fly by Glenn Curtiss, but when he crashed it and Curtiss said it would be months before the repair parts would be available, Boeing figured he could build his own plane in less time. Based in Seattle, where a plentiful supply of spruce wood to build planes existed, Boeing built a line of amphibious aircraft, later a dedicated mail plane, and when he fielded an early airliner, the 247, he also started an airline to use that plane, and a tech company to build instruments and parts for it. When the Air Mail Act of 1934 forbade manufacturers from owning airlines, Boeing sold out and his three companies went their separate directions: Boeing aircraft, United Air Lines, and United Technologies. All three prosper today, but that prosperity has little to do with William Boeing.
Boeing the aircraft company did not really take off (especially after 247 airliner was smoked by Douglas with their DC3), until Claire Egtvedt (who was college educated, but hired on as a draftsman) took over as CEO, and pushed the company in the direction of larger planes. This led to the B17 and B29 bombers, and 307, 314, 377, 707, 727, 737, 747, etc... airliners.
Some of Boeing's success was situational. While the first jet liner was built by De Havilland (the Comet), Boeing built the first jet liner that didn't come apart in the air... an important distinction. De Havilland never really recovered from the Comet disaster, while Boeing rode the 707 to even greater heights.
So one can paint a misleading narrative that large companies were 'founded' by people without higher education, by simply being selective in who they define as 'founder'. In these cases, the person who can be said to be 'the founder' was not the person who made the company truly successful... that person almost always having a higher education degree.
The assertion that most companies in the US in the late 1800's and early 1900's were started by tradesmen without higher education is false... when you investigate how those companies became successful.