77

Yes. That is: They can cause hearing loss. They are properly classified as ototoxic agents. Paracetamol/Acetaminophen is certainly not entirely harmless. In fact it is properly classified as an ototoxic drug. An effect observed for quite some time. According to the individual studies: This is more pronounced when using it in each of these cases: higher ...


60

Yes, there was such a study, if by "medically effective", you mean something like "better than not using any epinephrine treatment". From the NIH, a study first published in the Journal of Allergy and Clinical Immunology titled "Outdated EpiPen and EpiPen Jr autoinjectors: past their prime?": For prehospital treatment of anaphylaxis, we recommend the use ...


42

Yes, with a number of caveats. Shkreli's company, Turing Pharmaceuticals, promised to give free access to Daraprim to some patients in need after the initial price-hike controversy arose. Here is a timeline: February 2015: Martin Shkreli founded Turing Pharmaceuticals. September 2015: Turing Pharmaceutical raised the price of Daraprim from $13.50 to $750 ...


30

I have done some research on the drug. I find the drug extremely scary. The video in the question was of fairly low quality when it came to science, for shock value it was high quality though. Digital Journal That may be why in more recent years, the U.S. State Department issued a warning telling travelers to beware of "criminals in Colombia using ...


30

Depends on how you define "profitable". But either way it's not the top one. I couldn't find more recent data, but in 2008 pharmaceutical industry wasn't the most profitable, although it was high in various rankings, not so high in others (source CNN): Profit as percentage of revenue Network and Other Communications Equipment 28.8% Mining, Crude-Oil ...


24

Concerning the claim in the question headline: it might be difficult to properly define "very little", compare that to Western medicine. Then start an argument about what counts statistically as… Thankfully such claimants are inclined to use the absolute. "during the USSR's 70 years of existence, no new תרופה [i.e. cure/medication] was developed". (...


21

The closest I could find was this (see also here): He also promised: "If you cannot afford the drug we will give it away for free." This was after the backlash because of the severe price inflation. I found no evidence that he personally or the company ever actually followed up on that (I doubt it though).


21

The referenced study is likely "Analgesic Use and the Risk of Hearing Loss in Women" in the American Journal of Epidemiology. The conclusion states In conclusion, this prospective study showed that use of ibuprofen or acetaminophen 2 or more days per week is associated with an increased risk of hearing loss in women and that the magnitude of the risk ...


20

Oxycontin (oxycodone) and heroin are both opioids, but not exactly the same substance. So, no, Oxycontin is not "pharmaceutical grade heroin" — thats an oversimplification to say they're both opioids (so they work in a similar way). Just take a look at their molecular structures to see that they're similar, but different: Heroin: Oxycodone:


20

A search in the Pubmed database for "soursop cancer" (which is automatically expanded to ("annona"[MeSH Terms] OR "annona"[All Fields] OR "soursop"[All Fields]) AND ("neoplasms"[MeSH Terms] OR "neoplasms"[All Fields] OR "cancer"[All Fields]), so it will not only show exact matches) shows 43 results, though none of those are trials in humans. One of those ...


18

In short, yes. Picking one of the first recent publications to come up in my search for "honey wound healing", I give you Honey and Wound Healing: An Update (DOI 10.1007/s40257-016-0247-8), which "outlines publications regarding honey and wound healing that have been published between June 2010 and August 2016". The "key points" listed in the electronic ...


12

tl;dr- No, drinking distilled kerosene doesn't cure cancer as far as any modern research can tell. Some studies have suggested that it might cause cancer in some cases, though the general scientific opinion hasn't found a strong connection between kerosene and cancer under typical conditions. There's been a lot of research looking for cancer-causing ...


12

It seems a bit weird for any parent to want to sign their newborn up for drug trials. Weird or not, that's how it's done. If your kids are at risk of a dangerous disease, free vaccination and healthcare accompanying the trial may be an attractive proposition, even if it's on an experimental basis. For example, "Tameris et al.: Lessons learnt from the ...


11

According them them, their 4 essential oils are Eucalyptol Menthol Methyl salicylate Thymol Menthol, Thymol and Eucalyptol do have known antibacterial effects. I'm having difficulty finding anything specifically on Methyl salicylate (wintergreen oil), but their claims of efficacy against plaque seem plausible. Additionally, a Japanese study comparing ...


10

Straight from the wikipedia article (emphasis my own): Research carried out in the Caribbean has suggested a connection between consumption of soursop and atypical forms of Parkinson's disease due to the very high concentration of annonacin.[3][4][5][6] According to Cancer Research UK, Annona muricata is an active principle in an unlicensed herbal ...


10

Yes, he did. He admitted this in his interview with Oprah Winfrey. Oprah: Did you ever take banned substances to enhance your cycling performance? Lance: Yes Oprah: Yes or no, was one of those banned substances EPO? Lance: Yes


9

The evidence does not suppor the claim conclusively. There is a 1% increased risk of death per year due to atypical anti psychotic drugs such as olanzapine: The risk differences for death in patients treated with [...] olanzapine vs placebo, 0.01 (95% CI, −0.00 to 0.03; P = .07) --Risk of Death With Atypical Antipsychotic Drug Treatment for ...


9

There is significant evidence that Propoxyphene is more dangerous than its alternatives. The study "Co-proxamol overdose is associated with a 10-fold excess mortality compared with other paracetamol combination analgesic" published in 2005 in the British Journal of Clinical Pharmacology states: When related to prescription volume overdoses involving co-...


8

There is no conclusive evidence for or against amphetamine affecting creativity. Martha Farah's comments are liklely based on a small study (linked here) she and colleagues ran in 18 participants. The tasks were brief puzzles (rather than longer meaningful tasks one might expect to be sensitive to drugs that enable prolonged focus). Results were fairly ...


8

It depends what you mean by "smarter" but there are real beneficial effects in some areas Modafinil is widely believed (and widely used) to create some sort of cognitive enhancement. But the evidence has been a little mixed and often thought to be driven by its impact on sleep-deprived people (which is related to the licensed use). A recent systematic ...


8

The paper "Aspirin compared with acetaminophen in the treatment of fever and other symptoms of upper respiratory tract infection in adults", published by the NIH, tested the efficacy of Aspirin, Acetaminophen (Paracetamol), and a Placebo for fever reduction. (In the USA, Paracetamol is commonly known as Acetaminophen.) They tested 392 patients at two ...


8

There's a lot of literature on this apparently, and I've only looked at one (55-page) 2018 NBER paper. There is some (correlational) evidence that the "pill mill" crackdown contributed to the switch to heroin, although this paper favors the oxy reformulation as the key event. We attribute the recent quadrupling of heroin death rates to the August, 2010 ...


7

I haven't found a credible source which says that it is effective, by looking at the types of web sites returned by the https://www.google.com/search?q=psychosis+niacin search and similar searches for related terms (i.e. "B3" and "schizophrenia"). Wikipedia on Abram Hoffer says, Hoffer's theories on schizophrenia and nutrition were generally discredited ...


7

There has not been any statin vs statin comparisons, but there was a comparison of different dosages of the same statin. 10,001 patients were either assigned to treatment with either 10 mg of atorvastatin or 80 mg of atorvastatin. The primary end point was the occurrence of a first major cardiovascular event, defined as death from CHD, nonfatal non-procedure-...


7

Ranbaxy is a good example of a company that simply faked a lot of their data. Katherine Eban wrote a very good article in Fortune that summarizes the episode: Ranbaxy pleaded guilty to seven federal criminal counts of selling adulterated drugs with intent to defraud, failing to report that its drugs didn't meet specifications, and making intentionally ...


7

How much antibiotics affect gut flora is open subject, there are studies showing there is long lasting negative effect. Eg. "Gut microbiota disturbance during antibiotic therapy: a multi-omic approach" This matters, because gut bacteria does help immune system. Part of an abstract of paper published in the European Review for Medical and Pharmacological ...


7

The image is incorrect in its description, but on target for costs being different in the USA and India, but jumps to hyperbole for its reasoning. The pill in question is Sovaldi, manufactured by Gilead Sciences as a Hepatitis C cure. The cost for the full course of treatment is $84,000 in the USA, and $900 in India. Thus the numbers quoted in the image ...


7

TLDR version: the jury's still out. There's limited evidence of improvement in narrow tasks, mainly in memory (particularly on stimulants) and in some sub-groups of individuals. There's also a divergence of results on short and long term effects (mostly noted on modafinil)... possibly due to publication bias. Motivation has been offered as a more important ...


7

Just to focus on one of the specific claims, a journal article from 2009 describes what the authors believed to be the first clinical application of shea butter to treat eczema (aka atopic dermatitis). The results were favorable but the only conclusion they drew was that further study might be worthwhile. A more recent article from 2018 provides a meta-...


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