61

Yes, there was such a study, if by "medically effective", you mean something like "better than not using any epinephrine treatment". From the NIH, a study first published in the Journal of Allergy and Clinical Immunology titled "Outdated EpiPen and EpiPen Jr autoinjectors: past their prime?": For prehospital treatment of anaphylaxis, we recommend the use ...


42

Yes, with a number of caveats. Shkreli's company, Turing Pharmaceuticals, promised to give free access to Daraprim to some patients in need after the initial price-hike controversy arose. Here is a timeline: February 2015: Martin Shkreli founded Turing Pharmaceuticals. September 2015: Turing Pharmaceutical raised the price of Daraprim from $13.50 to $750 ...


34

That is an incorrect statement, if we're stricts. Bone marrow transplant to cure children lymphoma is a good example of a cure developed after the 50's: http://www.fhcrc.org/science/clinical/ltfu/faqs/transplantation.html . The major breakthrough was to obtain successful allogeneic grafts, which was not possible before late 60's-early 70's. There's a ...


30

Depends on how you define "profitable". But either way it's not the top one. I couldn't find more recent data, but in 2008 pharmaceutical industry wasn't the most profitable, although it was high in various rankings, not so high in others (source CNN): Profit as percentage of revenue Network and Other Communications Equipment 28.8% Mining, Crude-Oil ...


30

I have done some research on the drug. I find the drug extremely scary. The video in the question was of fairly low quality when it came to science, for shock value it was high quality though. Digital Journal That may be why in more recent years, the U.S. State Department issued a warning telling travelers to beware of "criminals in Colombia using ...


24

Concerning the claim in the question headline: it might be difficult to properly define "very little", compare that to Western medicine. Then start an argument about what counts statistically as… Thankfully such claimants are inclined to use the absolute. "during the USSR's 70 years of existence, no new תרופה [i.e. cure/medication] was developed". (...


21

The closest I could find was this (see also here): He also promised: "If you cannot afford the drug we will give it away for free." This was after the backlash because of the severe price inflation. I found no evidence that he personally or the company ever actually followed up on that (I doubt it though).


20

Oxycontin (oxycodone) and heroin are both opioids, but not exactly the same substance. So, no, Oxycontin is not "pharmaceutical grade heroin" — thats an oversimplification to say they're both opioids (so they work in a similar way). Just take a look at their molecular structures to see that they're similar, but different: Heroin: Oxycodone:


20

A search in the Pubmed database for "soursop cancer" (which is automatically expanded to ("annona"[MeSH Terms] OR "annona"[All Fields] OR "soursop"[All Fields]) AND ("neoplasms"[MeSH Terms] OR "neoplasms"[All Fields] OR "cancer"[All Fields]), so it will not only show exact matches) shows 43 results, though none of those are trials in humans. One of those ...


20

The first two parts are easy to address. From the FDA's own website: The mission of FDA's Center for Drug Evaluation and Research (CDER) is to ensure that drugs marketed in this country are safe and effective. CDER does not test drugs, although the Center's Office of Testing and Research does conduct limited research in the areas of drug quality, safety, ...


18

The title question isn't really answerable. But there are certainly other sources which bear on that estimate. I'm going to gloss over the different estimates here for a moment. The article claimed the W&L estimate was $55M, one of the authors (I'll quote below) claimed $59M, and I've heard $43M and $53M in reference to this article... let's just say "...


18

In short, yes. Picking one of the first recent publications to come up in my search for "honey wound healing", I give you Honey and Wound Healing: An Update (DOI 10.1007/s40257-016-0247-8), which "outlines publications regarding honey and wound healing that have been published between June 2010 and August 2016". The "key points" listed in the electronic ...


14

Let’s have a look at the list of drugs approved in the USA in 2011 alone – particularly at the active ingredients, since presumably this is what the professor meant because it’s what “makes the cure tick”. Ioflupane, not a cure in the strict sense (a carrier for a radioactive iodine isotope) entered into the database in 2005. Spinosyn D, first described in ...


14

There's probably no way of reliably proving that those particular images are of "krokodil" users ( if you look at the comment section for the article linked in the question, one of the images is supposedly of a heroin addict ), but they could very well be - according to the resources below, in extreme cases krocodil can cause gangrene, which may lead to loss ...


12

The Numbers Sources: Top 200 Pharmaceutical Sales 2009 - U.S. Sales and Prescription Information 2009 The Shenanigans About a year ago, patients began trooping into the office of UCLA psychiatrist Andrew Leuchter, asking whether an antipsychotic drug called Abilify "might be right for them." Few appeared to be delusional, plagued by ...


12

tl;dr- No, drinking distilled kerosene doesn't cure cancer as far as any modern research can tell. Some studies have suggested that it might cause cancer in some cases, though the general scientific opinion hasn't found a strong connection between kerosene and cancer under typical conditions. There's been a lot of research looking for cancer-causing ...


12

It seems a bit weird for any parent to want to sign their newborn up for drug trials. Weird or not, that's how it's done. If your kids are at risk of a dangerous disease, free vaccination and healthcare accompanying the trial may be an attractive proposition, even if it's on an experimental basis. For example, "Tameris et al.: Lessons learnt from the ...


11

According them them, their 4 essential oils are Eucalyptol Menthol Methyl salicylate Thymol Menthol, Thymol and Eucalyptol do have known antibacterial effects. I'm having difficulty finding anything specifically on Methyl salicylate (wintergreen oil), but their claims of efficacy against plaque seem plausible. Additionally, a Japanese study comparing ...


10

Straight from the wikipedia article (emphasis my own): Research carried out in the Caribbean has suggested a connection between consumption of soursop and atypical forms of Parkinson's disease due to the very high concentration of annonacin.[3][4][5][6] According to Cancer Research UK, Annona muricata is an active principle in an unlicensed herbal ...


10

Yes, he did. He admitted this in his interview with Oprah Winfrey. Oprah: Did you ever take banned substances to enhance your cycling performance? Lance: Yes Oprah: Yes or no, was one of those banned substances EPO? Lance: Yes


9

There is significant evidence that Propoxyphene is more dangerous than its alternatives. The study "Co-proxamol overdose is associated with a 10-fold excess mortality compared with other paracetamol combination analgesic" published in 2005 in the British Journal of Clinical Pharmacology states: When related to prescription volume overdoses involving co-...


9

I copy below the side effects reported on MedlinePlus (part of the National Library of Medicine, NIH). Every drug may have side effects. Those will vary with every person and the dosage used. If you read the prospect that comes with the drug, you can find all the reported side effects in there. It will include the side effects observed during the clinical ...


9

The evidence does not suppor the claim conclusively. There is a 1% increased risk of death per year due to atypical anti psychotic drugs such as olanzapine: The risk differences for death in patients treated with [...] olanzapine vs placebo, 0.01 (95% CI, −0.00 to 0.03; P = .07) --Risk of Death With Atypical Antipsychotic Drug Treatment for ...


8

I've started a community wiki to consolidate the answers. The professor I spoke with mentioned one drug that was discovered, alas serendipitously, by Barnett Rosenberg that effectively cures (with over 85% success) testicular and ovarian cancer: Cisplatin. This is an ideal counter-example to the skepticism (though at it's heart the skepticism is about the ...


8

There is no conclusive evidence for or against amphetamine affecting creativity. Martha Farah's comments are liklely based on a small study (linked here) she and colleagues ran in 18 participants. The tasks were brief puzzles (rather than longer meaningful tasks one might expect to be sensitive to drugs that enable prolonged focus). Results were fairly ...


8

It depends what you mean by "smarter" but there are real beneficial effects in some areas Modafinil is widely believed (and widely used) to create some sort of cognitive enhancement. But the evidence has been a little mixed and often thought to be driven by its impact on sleep-deprived people (which is related to the licensed use). A recent systematic ...


8

The paper "Aspirin compared with acetaminophen in the treatment of fever and other symptoms of upper respiratory tract infection in adults", published by the NIH, tested the efficacy of Aspirin, Acetaminophen (Paracetamol), and a Placebo for fever reduction. (In the USA, Paracetamol is commonly known as Acetaminophen.) They tested 392 patients at two ...


8

There's a lot of literature on this apparently, and I've only looked at one (55-page) 2018 NBER paper. There is some (correlational) evidence that the "pill mill" crackdown contributed to the switch to heroin, although this paper favors the oxy reformulation as the key event. We attribute the recent quadrupling of heroin death rates to the August, 2010 ...


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