The meme is unclear
It is not clear whether the meme is talking about absolute numbers or per capita murder rates. I'll talk about both.
The meme does not distinguish murder vs homicide
The first thing to note is that murder is a legal term, not equivalent to homicide. Murder does not include accidents or various manslaughter that led to homicide without ...
This is not possible based on the information given. The link you provided has the US at 6th with 16,214 murders and 189th place is a 3 way tie with 9 murders each.
Using this data that would require that those 6 cities accounted for all but 9 murders in the country.
If you look at the overall stats for the country you will find this is impossible.
This is false no matter what way you try to frame it.
Using the 2019 crime stats:
US: 15020 
Chicago: 491 
Detroit: 273 
New Orleans: 120 
St. Louis: 194 
Washington DC: 166 
These cities have a combined census population of 4.67m (out of 308.75m for the USA), which is ~1.5% of the total US population 
Removing those 5 cities ...