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I happened to know personally a guy in a depression phase of [bipolar disorder][1] and that is certainly a disease! anything, that causes the malfunctioning of the primary functions is a disease. The weight loss, hair loss, sleep deprivation, anhedonia - are the signs of the violated brain chemistry. Though one may cope with depression without medications - it's still a chemistry correction, whether you rapidly do sports or stick to extremal activities... [1]: http://undepress.net/bipolar-disorder-sings-symptoms-and-types-of-manic-depression/