Can an animal develop an affinity for manflesh? Would a tiger like human meat so strongly that it goes after humans?
Yes; The Man-Eaters of Tsavo by Lt. Col. John Henry Patterson tells the (amazing) story of two lions that may have killed and (at least partially) eaten as many as 135 (!!! But perhaps "just" 35) railroad workers in Kenya at the turn of the 20th century. Whether they had developed an "affinity for manflesh" or were driven to hunting humans due to a lack of other prey is, apparently, still a matter of debate. You can see the hides of the original Tsavo lions in the Field Museum in Chicago.