I smoked my head off and can't feel anything. And my friends can get high just by breathing all the smoke in the room :)

Someone told me that I need to try more and get used to it, and it will happen at some point. On Yahoo Answers I read that there's a small percentage of people who are immune to THC.

So which one is it? Will I ever be able to get high?

Edited to show notability: Here are some of the places the question is being asked (and often answered without the rigour we expect here): A B C D

  • Erowid is a great resource, but I don't see the specific claim addressed. If you found it somewhere on their site, can you direct us there? – John Rhoades Oct 10 '11 at 14:05
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    @Sklivvz How would data on the typical results shed light on a question about atypical results? Or are you referring to the "Caution : Reactions and experiences may vary dramatically from person to person." which would indicate that the claim is possible? – John Rhoades Oct 10 '11 at 20:05
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    Anecdotally it is most likely poor smoking technique. Try baking a large dose into some cookies. Leave about 30 minutes between eating each cookie, it is easy to eat too much before you feel the effects and that can be quite horrifying! – Mongus Pong Oct 11 '11 at 13:42
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    Also anecdotally: I spent a small fortune on raw and processed product, including the seedless variety, in my long-ago youth trying to achieve what seemed to come easily to others, and all I ever got out of the deal was soreness in my upper respiratory tract, occasional gut-rot from ingestion, and a greatly depleted savings account. Would that I had as little succeptibility to other things... – Stan Rogers Oct 13 '11 at 5:34

There is evidence that cannabis sensitivity varies considerably:

CONCLUSIONS: Genetic variation in AKT1 may mediate both short-term as well as longer-term effects on psychosis expression associated with use of cannabis, possibly through a mechanism of cannabinoid-regulated AKT1/GSK-3 signaling downstream of the dopamine D(2) receptor.

Whether one can sensitize oneself has not, as far as I can tell, been studied, but generally repeated exposure to a substance will desensitizes you.

Incidentally, cannabis is thought to be correlated with psychosis risk and other mild but measurable cognitive deficits (even when not high):

Compared to controls, cannabis users showed significant impairments on quality of decision-making (Cambridge Gamble task), and executive planning (One Touch Stockings of Cambridge task).

In the absence of evidence that all negative side-effects depend on the ability to get high (psychosis: yes; executive planning: I don't know), and in the absence of evidence that one could gain sensitivity, it might be prudent to avoid taking large doses for long periods of time in an attempt to achieve an enjoyable psychoactive effect.

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