A recent "The Joe Rogan Experience" episode with Bill Maher as the guest discussed weight loss drugs, especially type-2 diabetes GLP-1 agonists. The following interchange took place (J is Joe Rogan, M is Bill Maher):
J: You're taking an injection that makes you less hungry somethings going on. [Which is] Probably not good.
J: You're also losing a lot of connective tissue bone mass and muscle mass. My good friend Peter Attia did a study on he’s patients. He's a doctor did a study on patients that took Ozempic and one of the things they found is they lost weight, but they gain fat. They were actually had a higher percentage of body fat because they were primarily losing muscle tissue and connective tissue. They were losing so much of that that even though the they lost like 20 pounds they actually went from like 15 body fat to maybe 20 body fat or whatever the number was.
I was not able to locate the study mentioned in published literature. The closest match was this writing matching the topic and author.
- Are there documented instances matching the description from the show for people taking Ozempic? (Layman: Does weight loss from Ozempic come mainly from muscle loss?)
- If so, is this more general phenomenon associated of GLP-1 agonists drugs? (Layman: Do all GLP-1 drugs cause this?)