In her book, Kiss Your Dentist Goodbye, Ellie Phillips DDS recommends wiping a baby's teeth with xylitol enriched baby wipes to reduce tooth decay:

For added protection and to ensure your baby's mouth is healthy before teeth begin to erupt, wipe his or her gums with a 100% xylitol wipe such as Spiffies..

..Baby wipes containing xylitol can also be useful (to promote growth of healthy bacteria)

While there's a plethora of evidence proving how xylitol in chewing gum or candy reduces tooth decay I'm specifically interested in knowing if there's direct evidence proving that xylitol which is merely applied topically has the same benefit of xylitol that is ingested.

Spiffies (the manufacturer of xylitol baby wipes) claims that:

An independent study done at the University of San Francisco Dental School shows that Spiffies do reduce cavities in baby teeth

Similarly, while xylitol is generally well tolerated, some people experience digestive side effects. Others maybe concerned of a potential link between excessive xylitol consumption and cancer. If xylitol can provide equal benefit by being swished around the mouth, it would be super useful for those individuals.

What scientific evidence exists to show that xylitol which is applied topically (or swished around the mouth without being ingested) is equally as effective as xylitol which is ingested through chewing gum or candy?

1 Answer 1


That's an interesting question!

So I will first explain the exact mechanism of Xylitol in our oral cavity.

Xylitol, is a naturally occurring five-carbon sugar polyol, a white crystalline carbohydrate.

Now the most significant contributor or the pioneer bacteria for dental caries (which further leads to tooth decay) is Streptococcus Mutans.

Xylitol reduces the levels of mutans streptococci (MS) in plaque and saliva by disrupting their energy production processes, leading to futile energy cycle and cell death. It reduces the adhesion of these microorganisms to the teeth surface.

Xylitol, like any other sweetener, promotes mineralization by increasing the salivary flow when used as chewing gum or large xylitol pastille. The uniqueness of xylitol is that it is practically nonfermentable by oral bacteria. Also, there is a decrease in levels of MS, as well as the amount of plaque, when there is habitual consumption of xylitol.

You can read in more detail about the mechanism of action from the reference website

Overall benefits of Xylitol in the oral cavity-

Xylitol decreases the incidence of dental caries by increasing salivary flow and pH13 and reducing the number of cariogenic (MS) and periodontopathic (Helicobacter pylori) bacteria, plaque levels, xerostomia, gingival inflammation, and erosion of teeth.

Now xylitol is available in number of preparations-

Non Topical

  • Xylitol chewing gum

  • Xylitol gummy bear snacks

  • Xylitol syrups


  • Xylitol mouth rinses

  • Xylitol dentrifices

  • Xylitol wipes

Both topical and non topical preparations are equally effective for reducing as well as prevention of dental caries. Except the xylitol wipes you may read about each of the preparations from the reference website

Now coming to the xylitol wipes.

A number of studies have been done for the efficacy of Xylitol wipes in dental caries of children. The American Academy of Pediatric Dentistry (2008)has recommended tooth wipes as an important tool for oral hygiene care in infants and toddlers.

According to one such study

Our study clearly showed a significant reduction of new caries lesions in young children as a result of daily xylitol-wipe use, with 7 times fewer young children from the xylitol-wipe group developing new caries lesions compared with the placebo-wipe group.

In one more interesting study

Our study explored the anti-caries mechanisms of xylitol wipes on MS in our clinical trial, which showed marked inhibition of caries progression in young children who were treated with xylitol wipes. We first explored the genetic profile of MS colonization. Our results may suggest that MS colonization is less stable in the xylitol-wipe group as compared with the placebo-wipe group. This indicates that daily xylitol-wipe use may affect the stability of MS colonization in young children

However they found that there was no reduction in the number of MS bacteria. Hence one concluding statement for xylitol wipes by the previous study

These results suggest that, instead of reducing MS levels, the anti-caries effect of direct and indirect use of xylitol may have been achieved by modifying the virulence of the cariogenic bacteria or the ecology of the oral flora to be less cariogenic or less transmissible.

Some mechanisms have been proposed by several dentists for xylitol wipes-

She said the reason that a change in caries didn't correlate with a change in S mutans might be that other species of bacteria are involved. Dr. Zhang told Medscape Medical News that she agreed that this is one possible explanation. Another might be that xylitol changes S mutans in some way that makes it less virulent, she said. Or perhaps it affects the biofilm in which the organism works.


The xylitol wipes are also applied on the tooth along with the gums in those infants who can not chew gums.

Hence Xylitol wipes are equally useful for the reduction as well as in prevention of dental caries.

As a concluding statement I will suggest that rather than comparing gums vs wipes OP should look that both of them have got different indications. Though the mechanism of wipes has not been clearly understood, studies do suggest that it is effective in reducing as well as preventing dental caries in infants who have not learnt to chew. And after they grow old then xylitol gums can be easily chewed by them.

However, still if given a choice then definitely xylitol gums are more effective,-

Moreover, the act of chewing and suckling are potent stimulators of salivary flow which enhances the clearance of food debris, oral bacteria, and acid buffering capacity benefiting the remineralization of enamel and protecting from tooth decay. Reference

Hope I have satisfactorily answered your question :)

  • Thanks for your excellent analysis. I'm aware of the purported mechanism of the anti-caries effect of xylitol and that, "logically", the benefits should extend to topically applied xylitol. However, when tested using high quality controlled studies, expectations do not always pan in the "real world". And that is why I want emperical evidence which supports this assumption. Case in point, xylitol is expected to reduce tooth decay by "reducing the levels of MS in plaque and saliva by disrupting their energy production processes". Logically, there should be no difference between.. (cont)
    – S.O.S
    Jan 10, 2021 at 18:13
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    (continued) topical and ingested xylitol in this respect. Yet the study linked clearly demonstrates that the logic is incorrect "No significant differences between the two groups were observed in levels of mutans streptococci and lactobacilli at all time-points" which suggests that xylitol wipes may be effective due to an entirley different mechanism. This begs the question: Is topical xylitol the same effective as xylitol from chewing gum/candy? Are there any studies comparing the effectiveness of topically applied xylitol vs. xylitol ingested by chewing gum or eating candy?
    – S.O.S
    Jan 10, 2021 at 18:13
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    That's again a great question. I feel that the indications of wipes and gums are different. As toddlers can not consume gums, hence wipes have been made which even though not as effective as gums, but provide atleast some cariogenic effect, as compared to the toddlers on which wipes are not used. Wipes can be easily applied by the parents and there is no fear of choking in toddlers.
    – Ojasvi
    Jan 11, 2021 at 2:59
  • Rest I will share if I find some article/study to compare the effectiveness of xylitol gums vs xylitol topical wipes
    – Ojasvi
    Jan 11, 2021 at 3:00
  • @Ojasavi so far you gave a great reply. Probably award you the bounty even if you're not able to find research addressing the questions in the bounty. But if you do that would be amazing..
    – S.O.S
    Jan 18, 2021 at 23:57

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