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There was a study published in Neuro Endocrinology Letters by Dr. Ethan Russo in 2004 that says many diseases being treated with cannabis correlate with an “endocannabinoid deficiency”, but I cannot read the study or find any more information about this.

Do certain medical conditions correlate with an “endocannabinoid deficiency”?

  • Why is this question broad (Are there any diseases?) when the claim is more specific: "Migraine, fibromyalgia, IBS and related conditions display common clinical, biochemical and pathophysiological patterns that suggest an underlying clinical endocannabinoid deficiency that may be suitably treated with cannabinoid medicines."? – Oddthinking Aug 25 '18 at 7:41
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    The claim isn't that strong - it is suggesting a possibility that should be investigated experimentally. What would a "Yes" or "No" answer look like? – Oddthinking Aug 25 '18 at 7:43
  • @Oddthinking the reason I made the question broad is because the author says “and related conditions”, which seems to imply there are other diseases. For example, there may be evidence that seizures are caused by an endocannabinoid deficiency. A yes answer would include any other studies that have been done to confirm or deny this claim; or perhaps information from Russo’s study that either confirm his claims, or reasons why his claims are weak. – Cannabijoy Aug 25 '18 at 7:56
  • That sounds a lot more like a question for Psychology & Neuroscience SE. – Fizz Aug 25 '18 at 9:09
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    And ncbi.nlm.nih.gov/pmc/articles/PMC2241751 This latter contains these words: ... as well as mice deficient in cannabinoid receptors or the endocannabinoid-degrading enzyme fatty acid amidohydrolase. – Daniel R Hicks Aug 25 '18 at 12:30