it’s important to remember how many fatally overdose on [marijuana].
Zip. Zero. That’s according to the National Institute on Drug Abuse, which collects data on a range of other substances, both legal and illicit, and the Drug Enforcement Administration.
“It is well-established in the world medical literature that cannabis is incapable of causing death by lethal overdose,” Paul Armentano, the deputy director of the National Organization for the Reform of Marijuana Laws (NORML), told Healthline.
He cites, among others, one study that concluded, “There are no cases of fatal cannabis poisoning in the human medical literature.”
There have been no deaths definitively caused by an overdose on cannabis.
There is a "possible relationship" between cannabis and myocarditis, and myocarditis can be fatal, especially in children.
The authors report an 11-month-old male who, following cannabis exposure, presented with central nervous system depression after seizure, and progressed to cardiac arrest and died. Myocarditis was diagnosed post-mortem and cannabis exposure was confirmed. Given the temporal relationship of these two rare occurrences – cannabis exposure and sudden death secondary to myocarditis in an 11-month-old – as well as histological consistency with drug-induced myocarditis without confirmed alternate causes, and prior reported cases of cannabis-associated myocarditis, a possible relationship exists between cannabis exposure in this child and myocarditis leading to death. In areas where marijuana is commercially available or decriminalized, the authors urge clinicians to preventively counsel parents and to include cannabis exposure in the differential diagnosis of patients presenting with myocarditis.