A friend two years ago read an online article that claims antidepressants cause brain damage. I don't know which one, but I imagine it was something like this.

Do antidepressants cause brain damage?

  • related: does depression cause brain damage?
    – tedder42
    Apr 1, 2016 at 17:37

2 Answers 2


The article you refer to seems biased and misleading. It quotes multiple serious-looking papers, then reaches a conclusion not mentioned in any of them.

Several articles (e.g. this and this) claim that anti-depressants are not so efficient in curing depression - after you stop taking them, depression often returns.
One article reports a correlation between depression and later dementia. It doesn't mention anti-depressants.

The nearest thing to brain damage I could find is claims that anti-depressants cause the body to build tolerance, so after you stop using them the depression may be worse than before.

  • "several articles" - which articles? "One article" - be specific. "claims that anti-depressants cause the body to build tolerance" - specify your source. "depression may be worse than before" - says who?
    – Jamiec
    Mar 30, 2016 at 10:44
  • 1
    @Jamiec, It's all in the articles referred in the page. I now added some specific references.
    – ugoren
    Mar 30, 2016 at 11:13

Anti-depressants are medications targeting neurotransmitters in the brain. They don´t cause brain damage, quite opposite, they help the brain restore its function after damage, as occurs in stroke (escitalopram enhances cognition after stroke)

  • Sorry, I don't find this answer provides enough evidence. Oct 6, 2019 at 20:58

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