1. This Web MD article suggests that 30% people are vulnerable to dietary cholesterol.

Indeed, studies suggest that only about 30% of people are particularly susceptible to the effects of dietary cholesterol on blood cholesterol levels.

  1. This answer suggests no connection.

  2. These US government dietary guidelines (page 76) suggests it is safe to consume <300 mg (a little bit more that in 1 egg) of dietary cholesterol a day.

Which of these options are scientifically accepted? And is there any contradiction in these three different viewpoints?

  • 2
    "How" questions don't work well here. This question would be OK if worded like this: "does dietary cholesterol affect blood cholesterol?"
    – matt_black
    Jun 15, 2014 at 22:55
  • @Oddthinking that is what I was talking about in chat yesterday .. the duplication of questions on cholesterol intake and effect on blood levels.
    – HappySpoon
    Jun 18, 2014 at 4:20
  • @Oddthinking I made update to the question. Please, remove duplicate flag.
    – user19505
    Jun 18, 2014 at 14:18
  • -1: The claim is too vague. The existing answer (and answers to the "duplicate" question show that it has some effect on all people, but whether they are "particularly susceptible" to the "effects" is rather meaningless.
    – Oddthinking
    Jun 19, 2014 at 3:24

1 Answer 1


This meta-analysis from 1992 by Hopkins of 76 trials where food was supplied by a metabolic kitchen nicely answers this question. [1]

cholesterol kinetics

The rise in cholestrol on consuming cholesterol is closely tied to the baseline consumption of dietary cholesterol. So, you can see that if you're on a plant based diet ( or vegan ), with zero cholesterol intake, then consuming an egg containing 250 mg of cholesterol will raise your serum cholesterol by about 0.35 mmol/L (13.5 mg/dl) but if you're on an average american diet of 400 mg/day of cholesterol, then the rise is only 0.1 mmol/L (3.9 mg/dl). This is the reason why many studies were confused by the effect of eggs on dietary cholesterol as they didn't understand the relationship between baseline intake and added consumption.

I haven't read link 3 above, but usually dietary guidelines advise that you don't exceed your cholesterol intake by 300 mg/day but they do not advise that you should consume cholesterol. There is no biological need to consume cholesterol since we manufacture all of our requirements in the liver.

[1] Hopkins PN. Effects of dietary cholesterol on serum cholesterol: a meta-analysis and review. Am. J. Clin. Nutr. 1992 Jun;55(6):1060-70. PubMed PMID: 1534437. Full text

  • Could you provide reference for FIG 2?
    – user19505
    Jun 16, 2014 at 18:51
  • It's at the bottom of my answer. Full text is also available.
    – HappySpoon
    Jun 16, 2014 at 20:45
  • It's only abstract available in the link you provided.
    – user19505
    Jun 17, 2014 at 11:21
  • 1
    @user3394380 full text but note that at any pubmed reference, full text links are found at the top right of the screen layout. Cheers.
    – HappySpoon
    Jun 17, 2014 at 19:48

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