5

I see repeated claims, mostly from sources of highly questionable veracity, that Sucralose was developed while searching for new insecticides. ABC news also makes this claim in a summery of various sugar substitutes.

Origin: Another accidental lab creation, this sweetener was discovered in 1976 by scientists in search of new insecticides

Snopes has a similar claim regarding aspartame rated as false, but I'm not finding anything on this claim regarding Sucralose.

There's also this question about whether they work as insecticides, which concludes they don't.

  • This sounds like a red harring. Even if it were true, it would not mean that sucralose is toxic or that it is an insecticide. – nico Apr 13 '14 at 18:02
  • @nico - I know it sounds like a red herring. I'm just wanting to find out if it's factual or not. – Compro01 Apr 13 '14 at 22:16
4

It appears to have been discovered by a team including members from the sugar industry.

They were looking for ways to use sucrose as a chemical intermediate. Most synthetic processes involve multiple steps. I have not found what (if any) final product was in mind.

I can find no evidence that any of the participants were engaged in insecticide research.

I can find no evidence that Tate & Lyle, usually characterised as a sugar business, would have been aiming to synthesize an insecticide from sugar.


Researchers at Queen Elizabeth College, University of London, discovered sucralose in 1976, during a collaborative research program with UK sugar producer, Tate & Lyle, PLC.

From a Sucralose information site


Sucralose was discovered in 1989 by scientists from Tate & Lyle, working with researchers Leslie Hough and Shashikant Phadnis at Queen Elizabeth College (now part of King's College London).[5] While researching ways to use sucrose as a chemical intermediate in non-traditional areas, Phadnis was told to test a chlorinated sugar compound. Phadnis thought that Hough asked him to taste it, so he did.[5] He found the compound to be exceptionally sweet.

From Princeton


This article was written with the help of Professor Leslie Hough whose research student Shashikant Phadnis discovered sucralose

...

Curiously, these substances might still have been waiting to be tested for sweetness had not Shashikant Phadnis, a graduate researcher, misheard a telephone call requesting samples of the chlorinated sugars for testing. As the call came from a large sugar company it is perhaps understandable that Phadnis thought that the company had requested them for tasting and so he tried them himself. The results are available in UK patents 1 543 167 and 1 543 l68.

From New Scientist (allegedly)


Sucralose is manufactured by a proprietary, patented process developed by Tate & Lyle, and uses ordinary granulated sugar, similar to that used in the home, as the starting material. Sucralose is technically a chlorinated carbohydrate, and it is made by selectively replacing three hydroxyl groups on the sugar molecule with three chlorine atoms. There are multiple locations on the sugar molecule where hydroxyl groups can be replaced. The trick for making sucralose, to get the best taste, highest levels of purity and the best yield, is to ensure that the sugar molecule is chlorinated in very specific locations only.

From Tate & Lyle

Tate & Lyle is a global provider of distinctive, high quality ingredients and solutions to the food, beverage and other industries


Tate & Lyle, a British sugar company, was looking for ways to use sucrose as a chemical intermediate. In collaboration with Prof. Leslie Hough’s laboratory at King’s College in London, halogenated sugars were being synthesized and tested. A foreign graduate student, Shashikant Phadnis, responded to “testing” of a chlorinated sugar as a request for “tasting,” leading to the discovery that many chlorinated sugars are sweet with potencies some hundreds or thousands of times as great as sucrose. (Walters, 2000)

From Sucralose - an overview, Genevieve Frank, Penn State University

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