I happened to know personally a guy in a depression phase of bipolar disorder and that is certainly a disease! anything, that causes the malfunctioning of the primary functions is a disease. The weight loss, hair loss, sleep deprivation, anhedonia - are the signs of the violated brain chemistry. Though one may cope with depression without medications - it's still a chemistry correction, whether you rapidly do sports or stick to extremal activities. Thus, the symptoms of depression, that are potentially harmful to life, make depression a disease:
There is no denying that those who suffer from severe depression are ill. Depression can be debilitating and, in some cases, deadly. Physical symptoms such as nausea, vomiting, fatigue, chronic pain, diarrhea, insomnia etc. are common concomitants to major depression. https://www.psychologytoday.com/blog/evil-deeds/200809/is-depression-disease