Yes and no, while the $20 note is the most commonly encountered counterfeit bill in the United States, the $100 note is the most common counter fit bill in worldwide circulation.
It appears that the $20 note is typically the bill most likely to be attributed to being counterfeited in various factoids without that distinction. However, in journalistic articles that feature quotes attributed to representatives from the United States Treasury Department and the United States Secret Service the $100 note is cited as the most commonly counterfeited in world wide circulation.
The worldwide circulation is the interesting aspect of this questionanswer as there are a number of different techniques that are used by well funded-funded organizations for counterfeiting (from bleaching US$5 bills to turn into $100 note to making new ones with stolen engravings) that tend to provide indications as to where the bills are being produced.
Counterfeiting is a big enough issue that the Federal Reserve periodically releases reports about the problem. In a report issued onin January 2000, one of the key findings was as follows:
... the denomination with the largest amount of counterfeits, both in dollar terms (about $6 million) and as a proportion of notes processed (about 60 per million notes), was the $100 note.1
- See page 52 - 53 which includes a table summary of counterfeiting rates at Federal Reserve banks.