Is SLIT an effective treatment?
Their website has a FAQ which contains the following claim:
In the world-renowned Cochrane Review, a meta-analysis reviewed 22 studies involving 979 patients on sublingual immunotherapy and concluded that sublingual immunotherapy is a safe treatment which reduces symptoms and medication requirements in allergic rhinitis. SLIT is also endorsed by the World Health Organization and the ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines.
I did check and the Cochrane Review did find positive results:
We included a total of 60 randomised controlled trials in the review. Forty-nine were suitable for pooling in meta-analyses [...]. Overall, we found a significant reduction in symptoms (SMD -0.49; 95% confidence interval (CI) -0.64 to -0.34, P < 0.00001) and medication requirements (SMD -0.32; 95% CI -0.43 to -0.21, P < 0.00001) in participants receiving sublingual immunotherapy compared to placebo.
The active component of the product is serum, which I take to mean antiserum. Basically it is composed of the specific allergens tailored to one's particular allergies.
It is the same component used in subcutaneous injections and the therapy works based on the same science as those.
Sublingual immunotherapy is taken as drops or tablets, placed under the tongue 3 or more times/week, containing a specific allergen which interacts with the immune system to decrease allergic sensitivity.
Is Allergy EZ a scam company?
I still have a big question on the validity of AllergyEz itself: the serum should be custom-made based on the patient allergies, however I see no mention of this in the site. It may just be a crap site (it is certainly not very good as it's raising more than one eyebrow).
Finally, other answers claim this product is a scam. This is a completely different matter. They may claim that the product is X and in fact sell you Y -- similar to herbal V14gr@. This may be, and I would be cautious of products that are not marketed through mainstream means.
I've been investigating this a bit further.
Just like Monkey Tuesday, I've also contacted the firm, see email here, [mirror for when mailinator purges it], [source for headers]
With some digging around I discovered this company: "ALLERGY EZ, L.L.C.", registered in Hawaii.
The manager of the company and the sales manager share the same surname. Are they related? Possibly yes.
REVAIRX, the original brand mentioned in the email, is actually a registered trademark, which is actually a good sign - although it proves nothing.
The trademark is registered to MILTON RAMSEY DOCTORS L.L.C. which is registered as a company in Mesa, AZ in the name of the same owner as ALLERGY EZ, L.L.C.. The interesting bit here is that it is registered as a domestic L.L.C.. [Articles of Organization].
The address of Milton Ramsey Doctors is also a house (possibly now a funeral home?).
Digging even further, more and more companies are appearing in Mesa (all with the same people, same signatures). See for example HORLACHER ACQUISITIONS, L.L.C.
So it is a family-owned business. It sounds quite fishy for a medical company, but I still don't have any proof that it is a scam, and I do think it could be either way for what I've found so far.